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While GA-AuNPs show promising selectivity and dual-mode action, their efficacy is highly dependent on tumor vasculature and may be less effective in poorly perfused or hypoxic regions (Table 2)

Notably, some ferroptosis inhibitors such as iron chelators, Fer-1, Lip-1, ROSI (ACSL4 inhibitor), and Trolox (antioxidant vitamin E analog) have been demonstrated to significantly inhibit ferroptosis in NAFLD animal models induced by arsenic, CDE-fed, MCD-fed, HFD-fed, and so on, and attenuate liver inflammation reactions, lipid accumulation, and liver injury [134,135,136,137,138]

M., Bernstein, C., Dvorak, K
Four of the identified compounds have mutagenic potential (AMES negative) namely compounds 1 (Methyl methanethiolsulfonate), 13 (S-Methyl methanethiosulphonate), 26 (2-Methoxy-4-vinylphenol), and 29 (2-(hydroxymethyl)-2-nitro-1,3-)
Moreover, ferroptosis has been observed to coexist with programmed necrosis, particularly in the demise of neurons following hemorrhagic stroke (132)

Porquet D, Casadess G, Bayod S, Vicente A, Canudas AM, Vilaplana J, Pelegr C, Sanfeliu C, Camins A, Palls M, del Valle J
