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This is because when you lie down, the blood flow to the affected area decreases, causing swelling and inflammation to increase

10.1016/j.redox.2020.101550 10.1016/j.redox.2020.101550 [DOI] [PMC free article] [PubMed] [Google Scholar] Gao L, Zhuang J, Nie L et al (2007) Intrinsic peroxidase-like activity of ferromagnetic nanoparticles

(Modified from Barrett KE: Gastrointestinal Physiology

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H3N1 influenza A virus infection caused higher virus titers in the lung, inflammation around bronchi and in the parenchyma, and mucus exudates in the airways in cigarette smoke-exposed mice compared to the influenza virus alone (39)