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Symptoms of folate deficiency include weakness, fatigue, difficulty concentrating, irritability, headache, heart palpitations, and shortness of breath

Tydings, J., Vaccaro A.R.., Minotti, P.: Axial Low Back Pain: Minimally Invasive Laparoscopic Approach, Case 17, 136, In Master Cases: Spine Surgery
This activates the ubiquitin-proteasome system (UPS) and the autophagy-lysosome pathway, accelerating muscle protein degradation

In doing this, the potential of therapies that have a significant impact on a small subset is lost within the larger sample population