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In cases where patients present with both end-stage heart failure and end-stage liver failure, it is advisable to consider combined heart-liver transplantation, as isolated organ transplantation may not yield improved prognostic outcomes (196)

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Conversely, immune cells can have protective effects on OLs

Involvement of glutaredoxin-1 and thioredoxin-1 in beta-amyloid toxicity and Alzheimer's disease

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The enzyme also serves as a receptor for coronaviruses and other human viruses and influences immune function, cell proliferation, secretion, and angiogenesis (Luan and Xu, 2007)