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8 GIPR deficiency in mice leads to impaired glucose tolerance with reduced cell function, 9 while GIP overexpression results in improved glucose tolerance, enhanced cell function, and resistance to highfat dietinduced obesity

Hepatology 43, 173181 (2006)

Fras JP, Davies MJ, Rosenstock J, Prez Manghi FC, Fernndez Land L, Bergman BK, et al

The ominous octet, which includes 8 key pathophysiologic defects found to be present in T2D, is illustrated in Figure 1

However, if fatigue is severe, if it impacts your daily functioning, or if you notice any of these red-flag symptoms, do not hesitate to reach out to your healthcare professional
