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Because a 4.5 mg dose uses almost the entire vial, plan vial supply accordingly

Kiermayer C, Northrup E, Schrewe A, Walch A, de Angelis MH, Schoensiegel F, et al

Additionally, under certain situations that cause iron-catalyzed apoptosis, p53 can accelerate iron apoptosis by suppressing SLC7A11 expression, whereas p53 deficiency-induced increases in SLC7A11 decrease ferroptosis (24)

Interfaces 13 , 1907219084 (2021)

However, there is a clear distinction between "toxic" and "excessive." When you take a dose that far exceeds what your body can process at one time, you aren't necessarily poisoning yourself, but you are likely overwhelming your digestive system

The one study that compared 28 IU/m 2 per week with 56 IU/m 2 per week reported no significant difference between the groups in the change in mean height SDS and mean height velocity