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First, the effect is enzymatic and cumulative you are shifting a metabolic set-point over days and weeks, not triggering an acute hormonal event, which is why steady daily exposure matters more than any single large dose

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Notably, the presence of isothiocyanates (ITC) in cruciferous vegetables, in particular SF in broccoli, weaves a strong mechanistic thread through all of these epidemiologic findings

Metabolites of GRP produced by microbiota can be categorized into the following three groups: (i) GLs such as glucoerucin, (ii) ITCs such as SFN and erucin, and (iii) ITC-nitriles such as SFN-nitrile and erucin-nitrile