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The average number of targets per compound was 18.58, and the average composition degree per target was 1.82

They also had reduced kidney function, indicated by increased plasma urea and increased renal tubular IL-6 expression

Knock-out of the Igf2r / M6pr gene combined with Igf2 ko/ Igf1r ko could partly rescue growth retardation, a finding that was explained by IGF-II actions via the insulin receptor (INSR)

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