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Unmasking of Receptors some receptors have a masking protein covering the intracellular portion of a receptor, like the GPCR seen below for example

This behavior is advantageous for nanoparticle formation, leading to the assembly of protein complexes with a predominantly hydrophobic inner core, while hydrophilic residues are more likely to be presented on the particle surface, facilitating interactions with surrounding water/solvent molecules (Estrada and Champion, 2015) (Figure 3G)

Jason Pencek, DC, FNP @dr.jasonpencek | ISSCA

[DOI] [PMC free article] [PubMed] [Google Scholar] 76.Ibiza S, Garca-Cassani B, Ribeiro H, Carvalho T, Almeida L, Marques R, et al

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Certainly, the four-fold increase in retractions of original articles (to 26 retractions per 10 000 articles published in the Biological Sciences) in the Biological Sciences since 2010 is very worrying