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In addition, since L-theanine was shown to have a relaxing effect and gamma-aminobutyric acid (GABA) was an important inhibitory neurotransmitter, the mixture of L-theanine and GABA had a positive synergistic effect on sleep behavior, including sleep quality and duration in caffeine-induced awake rats, and the mechanism might be that the mixture could promote the expression of GABA receptor, which was conducive to sleep (38)

Potential dietary links to central sensitization in fibromyalgia: past reports and future directions

doi: 10.1371/journal.pone.0114969

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The treatment was well tolerated [47]

doi: 10.3389/fnut.2026.1804917 Received 05 February 2026 Revised 04 March 2026 Accepted 16 March 2026 Published 31 March 2026 Volume 13 - 2026 Edited by Berenice M Romn Calleja, National Institute of Medical Sciences and Nutrition Salvador Zubirn, Mexico Reviewed by Anindita Banerjee, Indian Council of Medical Research (ICMR), India Venkateswararao Eeda, University of Oklahoma Health Sciences Center, United States Updates Copyright 2026 Chen, Zou, Li, Liu, Liu, Yao, Peng, Liang, Chen, Huang and Huang