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Schleicher, E., Didangelos, T., Kotzakioulafi, E., Cegan, A., Peter, A., & Kantartzis, K

Systemic HPA axis

AMB, 100 mg/kg, was given for 3 days before CYP-induced HC in male BALB/c mice and, thus, enhanced the frequency of acetylcholine-inducible contraction in the bladder

Biochemical assays In vitro ubiquitylation assays The identification of cullinRING ligase subunits and the ARIH1 RBR-type E3 as TDMD effectors 10 suggested that ZSWIM8 performs ubiquitylation by the previously defined E3E3 mechanism, which is a variation on the canonical E1E2E3 pathway 35,36

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In addition, the NLRP3 inflammasome activation triggered by ROS was also reported in the ARHL and NIHL
