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Typical Clinical Ranges Loading Phase: 25 mg per week (subcutaneous injection) for 46 weeks Maintenance Phase: 2 mg every 12 weeks after the loading period Key Considerations Personalization: Dosage should be adjusted based on individual symptoms, sensitivities, and treatment response

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Functional regulation of Wnt protein through post-translational modifications

N Engl J Med 371(15):13691373

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