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While individual antioxidants show partial efficacy, synergistic formulations could enhance blastocyst formation rates by targeting multiple redox pathways simultaneously ( 5.2.2 Standardized dosing 5.2.2.1 Reproductive protocols Defining optimal dosages for supplements like melatonin (218 mg/day) is essential to balance efficacy and safety, especially regarding gestational and neonatal outcomes ( in vitro maturation (IVM) improve embryo quality, but standardized thresholds are needed to avoid toxicity and ensure reproducibility ( 5.2.2.2 Dietary interventions Standardizing components of the Mediterranean diet rich in antioxidants, monounsaturated fats, and polyphenols could improve IVF pregnancy rates by reducing inflammation and oxidative stress ( 5.2.2.3 Toxicity thresholds Establishing safe upper limits for supplements is vital