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NNMTi-treatment offers a promising therapeutic approach to address this unmet need 8,9,13

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Thus, it is possible that the senescent phenotype drives the accumulation of CD38 + inflammatory cells, which modulate the availability of NAD + precursors, and plays a crucial role in the metabolism of nicotinamide nucleotide (Figure 5) (65)

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Methylcobalamin injections are administered by licensed clinicians using medical grade protocols and are generally well tolerated

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