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Although these models require validation of genomic, epigenomic, metabolic and expression parity with the original GBM (because tumor specimens are exposed to culture), in our opinion, when generated and paired with defined clonal tumors and/or single cells reflecting the original tumor diversity, they provide a way to refine and further exploit these models

Control of cell cycle and immortality BORA BORA emerged as another target from Perturb-Seq analyses of radiotherapy-treated GBM

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