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The Importance of FIH Trials in Clinical Development First-in-Human trials provide the first opportunity to translate preclinical evidence into early clinical knowledge

Retrieved 21 November 2008

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Furthermore, we recently demonstrated that oral administration of Immunocal in the G93A mutant SOD1 mouse model of ALS delayed disease onset and preserved grip strength to a significant degree, in comparison to untreated transgenic mice [70]

Regarding manganese safety, it should be noted that the Mn 2+ content in the formulation is relatively low and predominantly exists in a coordinated state within MnUA rather than as free ions
