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Standard B12 blood tests strip B12 off all its carrier proteins and measure the total freed B12, so they cant distinguish between normal B12 and macro-B12: both contribute equally to the reading

doi: 10.3389/fphar.2017.00412 94

Primary Care-Based Study. Medicinski Glasnik: Official Publication of the Medical Association of Zenica-Doboj Canton, Bosnia and Herzegovina, vol

It also helps protect cells from further harm by reducing inflammation and defending against microbes

We showed that cirrhotic (an IGF-1 deficiency condition) rats had diminished amino acid and glucose intestinal absorption [114, 194, 195] and that IGF-1 replacement therapy was able to restore both alterations, suggesting a role of IGF-1 in the position of transporters [196]
