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10 Updated from the 2012 ACS guideline 5, the current ACS Diet and Physical Activity Guideline and recommendations (Fig

Psychiatry 121 , 110674 (2023)

However, currently available drugs fall short in some cases, prompting clinicians to search for therapeutic alternatives [9]

Representative drugs like the highly selective HIF-2 antagonist Belzutifan (MK-6482) [488] inhibit the expression of pro-angiogenic and pro-survival genes, alleviating abnormal metabolic burden and vascular disruption in tumor tissues

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