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Apart from enhanced glucose/fatty acid cycling, it has been shown that GH induced insulin resistance is accompanied by reduced muscle glycogen synthase activity (91) and diminished glucose dependent glucose disposal (92)

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In addition, the central clock system can regulate the rhythmic release of hormones such as melatonin and cortisol by linking to the neuroendocrine and autonomic nervous systems independently of sleep-driving hormones and other rhythms (Nicolaides et al., 2014)