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doi: 10.1088/1748-9326/11/10/105002/pdf 119

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Recent studies utilizing CRISPR screens and Perturb-map analysis have identified IL-4 as a key mediator of immune resistance, particularly in its ability to sustain an immunosuppressive niche that limits effector T cell activity

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[6] The action of 2,3-BPG is an example of heterotropic allosteric regulation, i.e., allosteric regulation in which the effector is different from the normal ligand of the protein