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BCL-2 antagonist ABT-199 combined with complex I inhibitor IACS-010759 blocks mitochondrial respiration and facilitates anti-leukemia effect in pre-clinical AML models
To test this hypothesis, we sought to alleviate the protein folding defects by transient overexpression of heat shock protein 27 (HSP27), a small protein chaperone with an antioxidant role in stress resistance

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Khan et al., 2010), followed by incorporation of sulfide into carbon skeletons to generate Cys via the Cys synthase complex in which Serine (Ser) acetyl transferase and O -acetyl-Ser(thiol)lyase cooperate to allow metabolite channeling (Fig

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Additionally, many Lewy bodies were observed in the cytoplasm (Fig
