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In spermatozoa, the proteins most affected by oxidative stress are those involved in maintaining the cytoskeleton, motility, and the acrosome reaction

This inhibition helps alleviate apoptosis in intestinal epithelial cells (IECs) and promotes the expression of tight junction proteins ZO-1 and occludin between these cells, ultimately leading to a reduction in damage to the intestinal epithelium (Li et al., 2022)

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Although subacute tears are still amenable to direct repair, in general they tend to regain less strength and range of motion than patients with repair of acute injuries

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Genetic testing is used to see if a person has the genetic variants that cause cvEDS
