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Each of these dehydrogenases has a range of substrate specificities determined by the length of the fatty acid

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The major pathological hallmarks of PD are represented by the progressive loss of dopamine(DA)-ergic neurons in the substantia nigra (SN) of the central nervous system (CNS) associated with cytoplasmic inclusions termed as Lewy bodies and Lewy neurites (Spillantini et al., 1997)

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Persistent DNA damage triggers checkpoint activation through kinases such as ATM and ATR, leading to cell cycle arrest