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The primary upstream mechanisms, oxidative stress and endocrine disruption, initiate a cascade of cellular dysfunctions in reproductive tissues [103]

126,127 Familial genetic mutations and polymorphisms can also alter astrocyte functions in ways that contribute to disorder progression as noted in Huntingtons disease, 117,128 familial amyotrophic lateral sclerosis (ALS) mutations, 129,130 or familial AD mutations

Consistent with increased glutamate levels and the pressure on energy metabolism, Rao et al

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Macha MA, Rachagani S, Gupta S, Pai P, Ponnusamy MP, Batra SK, et al