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Cosmetic use of botulinum A exotoxin

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Structure: H-D-Arg-2,6-diMe-L-Tyr-L-Lys-L-Phe-NH2 (C-terminal amidation) Indication: First therapy approved to improve muscle strength in BTHS patients Mechanism: Targets mitochondrial dysfunction underlying skeletal muscle weakness and cardiomyopathy FDA Approved Peptides by Therapeutic Category Metabolic & Endocrine Peptides (GLP-1 & GIP) The metabolic peptide sector dominates current prescribing patterns, with the GLP-1 receptor agonist class leading unprecedented demand: Peptide (Brand) Indication FDA Approval Manufacturer Semaglutide (Ozempic/Wegovy) Type 2 diabetes, Weight management, CVD risk 2017/2021 Novo Nordisk Tirzepatide (Mounjaro/Zepbound) Type 2 diabetes, Obesity 2022/2023 Eli Lilly Liraglutide (Victoza/Saxenda) Type 2 diabetes, Weight management 2010/2014 Novo Nordisk Dulaglutide (Trulicity) Type 2 diabetes, CVD risk reduction 2014 Eli Lilly Exenatide (Byetta/Bydureon) Type 2 diabetes 2005 AstraZeneca Lixisenatide (Adlyxin) Type 2 diabetes 2016 Sanofi Pramlintide (Symlin) Type 1 & 2 diabetes adjunct 2005 N/A 2026 Pipeline Update: Tirzepatide is under FDA review for pediatric indications with decisions expected in 2026, while semaglutide 7.2 mg and combination therapies (cagrilintide + semaglutide) are advancing through late-stage development

Transient receptor potential V channels are essential for glucose sensing by aldolase and AMPK

Weed Sci 39:324328 Vijayakumar H, Thamilarasan SK, Shanmugam A, Natarajan S, Jung HJ, Park JI, Kim H, Chung MY, Nou IS (2016) Glutathione transferases superfamily: cold-inducible expression of distinct gst genes in Brassica oleracea