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In this Critical Perspective, we discuss a central limitation of current Model-Informed Precision Dosing in critically ill patients: many dosing decisions are still based on intermittent snapshots of a physiology that is continuously changing

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Diagnoses included osteoarthritis (55.5 percent), chronic low back pain (51.5 percent), and neuropathic pain (24.8 percent, primarily in the feet)

Contaminated or incorrectly dosed peptides can be ineffective at best and harmful at worst

Acknowledgements We wish to thank our collaborators (Drs