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al eludirlas gracias a la sustitucin Glu3Arg y la extensin N-terminal de 13 aminocidos, Long R3 IGF-1 evita ese secuestro y la rpida depuracin, manteniendo concentraciones activas mucho ms tiempo

After a 24 h incubation at 37 C in a 5% CO 2 environment for cell adhesion, the media were substituted with new medium containing different doses of 1,25(OH) 2 D 3 or control solutions, based on initial dose-response investigations

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10.1016/j.ijbiomac.2016.01.090 360 ZhangF.JiangL

PLGA-based co-delivery nanoformulations: overview, strategies, and recent advances

Monoglutamate folate is absorbed through the reduced folate carrier (RFC), folate receptors (FR), and the proton-coupled folate transporter (PCFT) and is converted into its active forms, dihydrofolate (DHF) and tetrahydrofolate (THF), through OCM within the cell