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After 8 h, cells were harvested in Passive Lysis Buffer (Promega Corp., Madison, WI) and the luciferase activity was measured by the Nano Dual-luciferase report assay System (Promega Corp., Madison, WI)

doi: 10.1016/j.cellsig.2010.11.015

Relative to either monotherapy, the greater OHIP14 K reduction at week 4 indicates a faster onset of benefit and clarifies that the combination confers speed rather than sustained superiority

CoQ 10 also helps limit the production of mitochondrial reactive oxygen species and supports uncoupling protein function [68]

1 , 2 Therefore, switching to orally administered vitamin B 12 (1.5 mg/day) at discharge is reasonable

Since both the human and mouse FH-deficient cells used here were immortalized cell lines, we tested the effects of GSH succination on primary kidney cells isolated from Fh1 fl/fl mouse pups and on the human diploid fibroblasts IMR90