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2019;157(5):1279-1292.e11

Chlorogenic acid improves late diabetes through adiponectin receptor signaling pathways in db/db mice

When PLOOH is not rapidly neutralized as an PLOH by glutathione peroxidase 4 (GPX4) in time, PLOOH further reacts with ferrous ions, and the resulting lipid radicals, such as alkoxyl phospholipid radicals (PLO) and PLOO, react with PUFA-PLs ( 2 produced by the mitochondrial tricarboxylic acid (TCA) cycle and the reduction of nitrogen oxides by NADPH produce H 2 O 2 catalyzed by superoxide dismutase (SOD) and participate in the Fenton reaction of iron ( Figure 1A )

But its expensive ($150-300+ per session), requires ongoing clinic visits (1-3x/week), and has a half-life of only about 14 minutes

In terms of side effects and tolerability, the advantage goes to neither (comparable)

If at least one of the two tests were significant, a permutation-based mixed-effects model was established by 3000 random permutations of the group label using the permlmer and predictmeans functions in R package v.1.0.1 ( If the interaction term was significant for overall symptoms, we further examined the 15 subscales of the CARS to identify those that were the most affected by the treatment