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Notably, elevated PKM2 levels in the urine of diabetic patients, which are absent in healthy individuals, suggest its potential as a biomarker for early diabetic nephropathy

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Tan W, Liew JWK, Selvarajoo S, Lim XY, Foo CJ, Refai WF, et al

While in vitro studies suggest silybin can inhibit enzymes like CYP3A4 and CYP2C9, human clinical trials indicate that these interactions are rarely clinically significant at standard physiological doses
