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Once inside, cystine is reduced to cysteine, a rate-limiting precursor for the synthesis of glutathione (GSH) ( reduces cystine uptake, impairs GSH synthesis, and consequently diminishes the cells ability to detoxify lipid peroxides, thereby facilitating the onset of ferroptosis (Liu et al., 2023

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Jian L., Mei Y., Xing C., Rongdi Y., BMC Ophthalmol

10.1002/bit.26314

What are the molecular mechanisms underlying leptin resistance