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[DOI] [PMC free article] [PubMed] [Google Scholar] 67.Tan X., Zhang Y., Wang Q., Ren T., Gou J., Guo W., et al

Indirect damage, accounting for two-thirds of the radiation-induced cell injury, means ionizing radiation is able to react with substances in cells such as water to form toxic ROS (Xie et al., 2019)

Cells may be pleomorphic with enlarged vesiculated nuclei and prominent nucleoli
Furthermore, the combination of exosomes with biomaterials extends their retention time in target tissues, enables sustained release, and significantly enhances therapeutic outcomes, offering IUA patients a durable treatment option beyond the reach of conventional methods

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