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65 There are seven cullin-based E3s including the SKP1CUL1F-box-protein (SCF) complex, which consists of three invariable components, RBX1 (a RING-finger protein), CUL1 (a scaffold protein), and SKP1 (an adaptor protein) as well as one variable componentthe F-box protein

Funding This research was supported by Key Research and Development Program of Shanxi Province (202302140601014), Postgraduate Practical Innovation Project 2024SJ266

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A tryptophan derivative TD-26 attenuates thrombus formation by inhibiting both PI3K/Akt signaling and binding of fibrinogen to integrin IIb3