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This blockade of the signaling cascade results in a significant decrease in the mRNA expression and protein levels of key pro-inflammatory cytokines (such as TNF-, IL-6, and IL-1), thereby alleviating inflammatory cell infiltration and tissue damage ( Silybin can exert anti-inflammatory and protective effects in respiratory diseases such as pulmonary tuberculosis and pneumonia by promoting the expression of Th1-type cytokines, inhibiting the NF-B/MAPK pathway, and suppressing the activity of the NLRP3 inflammasome ( Table 2 )

Furthermore, previous research has revealed that specific lipid (containing cholesterol and glycosphingolipids) and protein-containing microstructural regions with LAMP2A are present on the lysosomal membrane