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However, allosteric modulators, both positive and negative, may offer superior efficacy with less danger of downregulation.

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Conclusively, these results suggest that ALC is capable to attenuate kainate-induced SE which is somewhat mediated through its lowering of oxidative stress, neuroinflammation, and pyroptosis that are related to its neuroprotective effect.

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In multiple human cancer cell lines, depletion of GGCT downregulated HIF-1 at the mRNA and protein levels

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