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Thus, the loss of intracellular GSH in the presence of active generation of hydroperoxy-phospholipids could occur through several active mechanisms, including formation of GSH, export of GSSG, inadequate replenishment of GSH, or insufficient levels of GSSG reductase, each directly or indirectly dependent on the generation of hydroperoxy-phospholipids

The alternative spliced forms were represented with the numeral following the gene name

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G.TicconiC.HalkierB

Also AFB1 can trigger caspase-3 activation and lead to apoptosis in rat liver [112] and in vivo studies suggest that AFB1can cause lipid peroxidation in rat liver [113]

For the migration assay, a procedure similar to invasion assay was performed using the migration chamber without Matrigel and 5 10 4 cells were seeded