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The ERK1/2 signaling pathway was also inactivated by inhibiting phosphorylation, thereby reducing autophagy responses and protecting nerve cells from oxidative stress (Ruan et al., 2024)
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The de novo synthesis of serine from 3-PG occurs in a chain of consecutive enzymatic reactions catalyzed by phosphoglycerate dehydrogenase (PHGDH), phosphoserine aminotransferase 1 (PSAT1) and phosphoserine phosphatase (PSPH)
Macrocyclization strategy for improving candidate profiles in medicinal chemistry