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Its potency is due to its ability to bind to IGF-1 receptors with the same affinity as IGF-1, though has a reduced binding that allows its biological actions not to be disrupted compared to IGF-1

In mammals, there are three major melanocyte specific enzymes catalyzing melanin biosynthesis: tyrosinase (TYR), tyrosinase associated protein 1 (TRP-1) and TRP-2

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