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2-Oxatricyclo [4.3.1.0(3,8)] decane exhibited a free energy of binding of 4.15 kcal/mol, suggesting a moderate binding affinity with the MexAB-OprM efflux pump.The inhibition constant (Ki) was determined to be 906.56 m, indicating a moderate inhibitory activity against the MexAB-OprM efflux pump

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Ethics declarations Ethics approval and consent to participate All animal experiments were approved by the Ethics Committee of Science and Technology Industrial Park, Guangzhou University of Chinese Medicine (PZ24115)