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Various studies have found that some ME/CFS patients identified by the Fukuda criteria have a significant excess relatedness for close (first or second degree) and distant (third degree) relatives (66, 68)

a low-valine diet has similar but more modest effects as a low-iLe diet, while the low-Leu diet has no effect

1 2 Rudolph G

These may include: Muscle cramps or weakness Increased heart rate Seizures in individuals with seizure disorders Worsening of hypothyroid symptoms Gastrointestinal discomfort in sensitive individuals If any of these symptoms occur, its important to discontinue use and seek medical advice immediately

569:23 6 Hongu N, DS

doi: 10.1016/j.molmet.2018.11.012 107 HiokiTSuzukiSMorimotoMMasakiTTozawaRMoritaSet al