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PMID: 9399445 Farmer, J., Vaccaro A.R.., Albert, T.J., Malone, S., Balderston, R.A., Cotler, J.: Neurologic Deterioration After Cervical Spinal Cord Injury

We show GSH depletion significantly decreased the level of Srebf1 (protein: SREBP-1c), a critical regulator of lipogenic gene transcription (Figure 3)

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However, recently, we reported a novel function for IRS-1 related to IGF-I signaling desensitization in L6 myoblasts: IRS-1 associates with the medium chain of the clathrin-coated adapter protein, AP2 and competitively inhibits its function