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Studies in mice revealed that dietary supplementation with TMAO, choline, or carnitine decreased reverse cholesterol transport (RCT) (Janeiro et al., 2018), a mechanism that counteracts excess cholesterol deposition in peripheral tissues by transporting excess cholesterol to the liver and small intestine (Ross and Glomset, 1973).The major pathway for cholesterol elimination is the metabolic synthesis of bile acids in the liver (Zarate et al., 2016), and it was reported that the size of the total bile acid pool was significantly smaller in mice administered TMAO (Koeth et al., 2013)

Treatments of sublethal stresses such as starvation early in life can prolong the nematode lifespan, but mutations in aak-2 greatly reduce or even eliminate the lifespan extending effects of these stresses

Vitamin C crosses the blood-brain barrier in the oxidized form through the glucose transporters

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