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This concept highlights the need to examine and define pharmacological principles (pharmacokinetic/pharmacodynamic, PK/PD) for the T cell targets themselves in addition to the pro-drug molecules (i.e

Swanberg K

When erastin and/or the iron compound ferlixit were used to induce ferroptosis in HEY, COV318, PEO4 and A2780CP ovarian cancer cell lines, it was found that erastin treatment was accompanied by NCOA4-mediated ferritin phagocytosis and mitochondrial dysfunction in HEY cells with high intracellular unstable iron pools (58)

Sharma, K., Attri, S

"Molecular cloning, sequencing, and expression of human myocardial fatty acid ethyl ester synthase-III cDNA"