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For the rest of the cycling genes, the core clock network might employ rhythmically expressed tissue-specific transcription factors which propagate the time-of-day signal

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doi: 10.1186/s12958-021-00789-y 86 WadhwaLPriyadarshiniSFauzdarAWadhwaSNAroraS

Nevertheless, ECT is one of the most effective treatment options for treatment-resistant major depression, and its potential benefits outweigh its risks in some cases

From a GABAergic perspective, adaptive plasticity mechanisms may be impaired in the aged brain due to a prevalenceof GABA A receptors showing different pharmacological kinetics and response to GABA compared to young animals