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HT should be suspected in any patient with a baseline serum tryptase value above 8 ng/mL since it is the leading cause of hypertryptasemia, affecting around 6% of the population [37, 54, 55]

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Because MS straddles the immune/degenerative divide, combining microbiome therapy with existing immunomodulatory drugs is an area of interest
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Furthermore, 19.6% of participants in the placebo group increased their antihypertensive treatment (compared with 8.4% with CagriSema), which may have impacted the ETD in BP between these groups
