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Nevertheless, Sartini et al

Unlike full growth hormone therapy, it does not raise IGF1 (Insulin-like Growth Factor 1) and does not cause systemic growth effects
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doi: 10.1146/annurev.nutr.28.061807.155438

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Despite significant progress in clinical RNAi drug development, there remains considerable room for improvement in pharmacokinetics, pharmacodynamics, and strategies to mitigate toxicity (Setten et al., 2019)
