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10.1016/j.neuroscience.2011.08.021 264 VolkowN

Oxidative stress has been implicated as one of the factors responsible for the pathogenesis of this disease, most likely contributing to the destruction of melanocytes (Mehaney et al

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Coord Chem Rev 445:214087

In addition, it should be taken into account that TCEP itself can suffer some decomposition in phosphate buffers at neutral pH ( AX Transformation Into DKP Implies a Loss of Reactivity and Antibacterial Potency DKP is a known metabolite of AX, considered to have lower or residual reactivity and bacteriostatic activity ( 1 H-NMR analysis of incubation mixtures containing equimolar amounts of DKP and butylamine revealed quantitative preservation of DKP (95% of the starting amount), thus confirming its lack of reactivity