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As they are a mixed cell population, they may use different types of energy sources, like glycolysis, glutaminolysis, and also fatty acid oxidation (14)

CA: cholic acid, CDCA: chenodeoxycholic acid, Cyp7a1: cholesterol 7-hydroxylase, Cyp7b1: cytochrome P450 family 7 subfamily B member 1, GLP-1: glucagon-like peptide-1, IL-1: interleukin-1, Ldl-R: low-Density lipoprotein-receptor, NF-B: nuclear factor-k-gene binding, Npc1l1: Niemann-Pick c1-like 1, TMAO: trimethylamine n-oxide, PXR: pregnane x receptor, Srebp2: sterol regulatory element-binding protein 2, TGF1: transforming growth factor-, TNF-: tumor necrosis factor-, UDCA: ursodeoxycholic acid

Using Ca 2+ fluorescence measurements, the Ca 2+ -transient duration, amplitude, and area under the curve were all significantly increased in the presence of 100 M TMAO (Figures 8AD), consistent with the increase in the Ca 2+ current observed in Figures 6, 7

During the Dose Optimization Period, subjects were titrated until an optimal dose, based on tolerability and investigator's judgment, was reached

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Sex-specific genetic effects across biomarkers