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22 Long-term use of glucocorticoids induces and exacerbates infections, cause hyperglycaemia, osteoporosis and even mental disorders

Unlike broad-spectrum approaches, this peptides D-retro-inverso structure provides enhanced stability and selectivity, minimizing effects on healthy cells

The type 2 nuclear receptors of most importance to drug metabolism and drug therapy include the pregnane X receptor (PXR), constitutive androstane receptor (CAR), and the peroxisome proliferator activated receptors (PPARs)

These free radicals can result from various stressors, including pollution, toxins, and even the natural processes of aging

In this review, we summarize the most recent advances on INDDs, including widely studied liposomes, LNPs, polymeric nanoparticles, protein and peptidebased nanoparticles, mesoporous silica nanoparticles, extracellular vesicles, and cell membranederived nanovesicles, focusing on design strategies for enhancing mucus and surfactant penetration, targeting specific lung lesions and cells, and stability during inhalation and storage