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Many patients use the terms Herxing or Herx reaction to describe a temporary worsening of symptoms after starting antibiotic treatment

85 A significant number of studies conducted in vivo and in clinical settings have shown that alkaloids possess diverse pharmacological properties, including anti-cancer, antiviral, anti-inflammatory

In a retrospective observational study, inhaled NAC therapy caused a significant inverse correlation between the mean change in the GSSG level and FVC, suggesting that the patients with more severe oxidative stress may be good responders to inhaled NAC therapy, as GSH replenished by NAC inhalation can partially reverse an oxidantantioxidant imbalance [170]

All concentrations (1.05.0% by weight) of gelatin (4.75 0.2) and CS-GSH (3.25 0.95) formulations have scored higher while HA-GSH (1.5 0.35) scored lower than GSH alone (2.75 0.61

The lack of success at Phase III was attributed to factors such as high baseline immunosuppressive therapy in patients and complex disease mechanisms in SLE, potentially limiting the application of Rituximab as a monotherapy in SLE (119)